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  • Well what Fred pointed out is that B12 supplementing lowers potassium levels. Low potassium causes tingling and numbness in extremities.

    I’ve taken 10 or 20 pills 99mg (3% of the RDA) of potassium to bring my levels up. I also use low sodium V8 juice and bananas to combat the tingling, both high in potassium. Every time I inject B12 I get tingling and deep cramping in my feet both signs of low potassium.

    BTW, if you are potassium deficient you are almost surely magnesium deficient since these electrolytes go hand in hand. Thats a little fact that I’ve never heard Fred mention.


    The problem with methylcobalaminmis that there are several different bacteria used in it’s production. Each bacterium has it’s own minor chemical variation on methylcobalamin with minor differences in some of the chemical groups. There has NEVER been any formal research into the differences between these beyond noting they exist.

    I have steictly tested 10 brands of mb12 with 4 other testers, all hypersensitive, for different reasons. In addition I have trialed perhaps another 20 brands. As I inject 3x per day, and I can tell the difference between a 5 star and a zero star b12 in 4 hours, between a 1-2 star mb12 and a 5 star in 24 hours, the difference between a 3-4 star and a 5 star mb12 in 2 weeks by the consistant effects on neurology. I have done comparative trials on over 500 10ml vials of mb12 and as many as 5 different batches concurrently. I had a “standard” batch of mb12 for about 2 years against which I could test all others. There is a HUGE difference. With a 5 star mb12 the numbness of my feet starts decreasing in hours. I feel each injection and they last about 8 – 12 hours before starting to wear off. A 3 star mb12 makes no such difference and body symptoms don’t return but body and CNS neurological symptoms start returning in a week. With a zero star mb12 body symptoms start returning in 3 days and CNS symptoms in 24 hours. This is the same as with cyanocbl, hydroxycbl and no b12 at all. The differences noted hold up across virtually everybody I have corresponded with for the past 9 years who have done comparisons. I have set up multiple trials of various kinds woth thousands of people. The decline of Jarrow mb12 was relatively recent. I take it to IMPROVE the performance of my 3 star injectable, the best I can find currently. It stopped improving on the injections and allowed a slow decline of CNS and peripheral nervous system in myself and a number of others that mentioned it. My assumption is that they bought a new kilo of mb12 crystal and their supplier sent them crystal from a different bacterium or production method or post production processing. It is likely nothing Jarrow has done except buy an mb12 crystal that isn’t as superior as the one they have used for the last 9 years.

    Folic acid and/or folinic acid in those who can’t convert them adequately to methylfolate competes with and effectively blocks abput 10+ times as much methylfolate. A person who has no such problem appears to top out on all methylfolate needs by 2400mcg, with folic acid provlems, 6000-8000mcg and those with folinic acid-veggie food source folate problems appear to need about 15mg +-seveal mg, such as the dose found most effective with Deplin (a prescription dose of Metafolin).


    Subsequent to the Ashkenazi type 2 diabetes genome scan, several investigators contributed linkage data for chromosome 20 to the International Type 2 Diabetes Linkage Analysis Consortium ( Womens LEA221277390 Derbys Grigio Antracite 556 Caf ynfpMkT5
    ), a collaborative effort organized principally by the National Institute of Diabetes and Digestive and Kidney Diseases to map genes for the disease. Common markers on chromosome 20 were genotyped, and results were combined for a total of 1,852 families. The initial results of this analysis suggested a peak of linkage at D20S107 with a logarithm of odds (LOD) of >3. We therefore decided to target this region in our search in Ashkenazi patients with type 2 diabetes.

    Gene mapping by linkage disequilibrium analysis in related families identifies broad conserved regions of chromosomal DNA. In contrast, “unrelated” affected individuals share smaller conserved chromosomal regions because there are many more meioses, resulting in greater recombination around the region harboring the disease gene. Theoretically, polymorphic markers in linkage disequilibrium with the disease locus can be used to find associations of regions containing the gene mutation.

    Linkage disequilibrium mapping has been shown to be an important tool for fine-mapping of monogenic diseases ( 10 Silk Rose Print Pussy Bow Dress Pink amp; Purple Valentino qLSt66
    ), and recently there has been success in identifying a gene involved in a complex disease—inflammatory bowel disease ( Herv 6icX8
    ). However, there is little doubt that linkage disequilibrium mapping for most other complex diseases will be more difficult ( 14 ). The distance over which disequilibrium extends between markers and disease loci is not well understood nor is the degree of genetic risk contributed by any particular locus, suggesting that genotyping closely spaced markers in many case and control subjects would be required. Single nucleotide polymorphisms (SNPs), whereas biallelic, have been preferred over simple sequence repeat polymorphisms for this type of analysis because SNPs are more abundant in the genome ( Mens U Mirvin B Mocassins Geox GYuhUZgyN
    ). As a general rule, the extent of linkage disequilibrium or association between a marker and a disease locus depends on the genetic distance between the two and the number of generations that have occurred since the mutation originated ( Ice Grey Strappy Tassel Longline Midi Dress Pretty Little Thing iQogjivG
    ). In isolated populations such as the Ashkenazi Jews, linkage disequilibrium has been shown to extend over a broad region ( 3 ). We therefore undertook a search for diabetes susceptibility gene(s) on chromosome 20q in Ashkenazi Jewish unrelated patients with diabetes. Here we report the initial results of our association studies with 91 validated SNPs spanning a 1-LOD interval (7.3 Mb) around the microsatellite marker D20S107 candidate region on chromosome 20. DNA from case and control subjects was genotyped in pools by a recently described method involving pyrosequencing technology ( 17 ). No significant associations have been found to date.

    Number and severity of episodes of tonsillitis or sore throat

    Number of days with sore throat

    Morbidity and mortality of surgery (measures of morbidity include complications of surgery and number of days with postoperative pain)

    Consumption of antibiotics

    Consumption of analgesics

    Absence or time off work or school

    Quality of life

    We sought data on the assessment of outcomes at three months, six months and 12 months, and in the second and subsequent years after randomisation.

    In the 2014 update, we added quality of life as an outcome not only because of the availability of data in two included studies, but also to acknowledge the importance of this outcome.

    We conducted systematic searches for RCTs. We placed no restrictions on language, publication year or publication status. The date of the last search was 30 June 2014, following previous update searches and original searches in 1999.

    We searched the following databases from their inception for published, unpublished and ongoing trials: the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL 2014, Issue 6); PubMed; EMBASE; CINAHL; LILACS; KoreaMed; IndMed; PakMediNet; CAB Abstracts; Web of Science; ISRCTN; ClinicalTrials.gov; ICTRP; Google and Google Scholar. In searches prior to 2013, we also searched BIOSIS Previews 1926 to 2012.

    We modelled subject strategies for databases on the search strategy designed for CENTRAL. Where appropriate, we combined subject strategies with adaptations of the highly sensitive search strategy designed by The Cochrane Collaboration for identifying randomised controlled trials and controlled clinical trials (as described in the Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, Box 6.4.b. ( Handbook 2011 )). We revised the subject search strategies for the 2014 update of this review. The new search strategies for the major databases are provided in Womens NELA Sling Back Heels Grey Stella GreyArles Grey7 UK 40 EU Chie Mihara HWFJRzWs
    and have been used in all subsequent update searches. The previous version of the search strategy is provided in Micro Rockstud leather derby shoes Valentino L4AI280iC

    We scanned the reference lists of identified publications for additional trials and contacted trial authors where necessary. In addition, we searched PubMed, TRIP database and Google to retrieve existing systematic reviews relevant to this systematic review, so that we could scan their reference lists for additional trials. We searched for conference abstracts using the Cochrane Ear, Nose and Throat Disorders Group Trials Register.

    At least two review authors independently screened titles and abstracts obtained from the database searches at different stages of the original review and subsequent updates. Similarly, at least two of the three review authors independently reviewed the full text of the potentially relevant titles and abstracts against the inclusion and exclusion criteria. We resolved differences by discussion.

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